The research performed at Dr. Yixian Wang's lab regards imaging and sensing tools for single entity analysis. Ongoing projects are (i) Study the molecular interactions between α-synuclein (αS) aggregates and neuron membranes for understanding the pathological mechanism in Parkinson’s disease (PD), (ii) Structural and morphological effects of nanoparticles (NPs) on their electrocatalytic properties, (iii) Fabrication and modification of carbon nanoelectrodes for intracellular detection of electrochemical active species and (iv) Real-time monitoring of particulate matter (PM2.5) in air sample via a novel hybrid imaging system.
A novel platform that combines the strength of various analytical techniques including scanning electrochemical microscopy (SECM), scanning ion conductance microscopy (SICM), atomic force microscope (AFM), patch-clamp and resistive pulse-based sensing and delivery, and surface plasmon resonance microscopy (SPRM).
This commerical SPRM system from Biosensing Instrument integrates optical microscopy and SPR, is a powerful technique for measuring binding activities of membrane proteins in vitro. It allows the simultaneous measurement of phenotypical changes of the sample via bright field and binding strength and kinetics via SPR.